I tried to once on my current computer, but I kept getting errors and such as I believe there were components missing.
I am however getting a new computer soon (Dual 2.5ghz G5, swish!) and I would like to try again.
Essentially what I'm looking for is either a list of all the stuff that FreeOrion relies on so that I can make sure they are installed before hand. If someone could even package all these things together with a single install script it would simplify things immensely!
Once I've got it running fine under Unix I can then start trying the the process of creating an application that runs natively in OS X. Once I've figured that out then I can start doing the same thing every time a new version comes out, and let some Mac users in on the action

I'll create a progress thread or add to this if I have any trouble